In the dead of night, Donovan (Liam McMahon) drives his girlfriend, Lucy (Anna Moore) and 4 friends to a secret rendezvous in the woods. They believe they are meeting a "medicine man" who can cure Lucy's terminal cancer, but they grow suspicious when a booby-trap in the road forces them to stop short of their destination, and one of them is brutally killed and dragged from the car.
The remaining 5 run for their lives to a deserted cabin, dodging the enchanted wolves that have slaughtered their friend and the bullets of the paramilitary commandoes that hunt them.
As the friends die one by one at the hands of the wolves, they realize too late that Donovan has set them up as bait in exchange for the wolf saliva he believes will heal his beloved's disease. But even Dylan is not prepared to pay the price for Lucy's cure.